We cannot rely on magical thinking: Herd immunity is not a plan – STAT – STAT

0 40

Ten months into the SARS-CoV-2 pandemic, there is mounting frustration that life is not back to “normal.” Many U.S. schools and businesses remain closed[1], people are hesitant to fly[2] and enjoy vacations, and in many places, restaurants and indoor activities are sharply limited, with severe economic consequences[3].

With patience wearing thin, it may be tempting to consider policies that give us a return to normalcy[4], whatever the consequences.

This wishful thinking describes the recent political consideration of herd immunity[5], a public health term that refers to the threshold at which enough people in a community are immune to an infectious disease so it cannot spread if reintroduced. Historically, herd immunity has been achieved only through the use of vaccines[6]. Trying to achieve herd immunity against SARS-CoV-2, the virus that causes Covid-19, without a vaccine is an idea that has come into vogue. But it is a misguided and dangerous approach that would not bring life back to normal, and would lead to the deaths of 500,000 or more Americans[7].

advertisement

Department of Health and Human Services Secretary Alex Azar testified last week[8] that “herd immunity is not the strategy of the U.S. government.” Yet President Trump has asserted[9] that with increased SARS-CoV-2 spread “you’ll develop herd — like a herd mentality. It’s going to be — it’s going to be herd developed — and that’s going to happen.” Scott Atlas, an adviser on the White House Coronavirus Task Force, has espoused such a plan[10].

Herd immunity protects those with vulnerable immune systems. Here’s how. Alex Hogan/STAT

It has also been reported that the White House “embraces”[11] the Great Barrington Declaration[12], a statement written by three infectious disease researchers who have since been joined the thousands of co-signers. This political statement, funded by the American Institute for Economic Research[13], a libertarian think tank, calls for allowing “those who are at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk,” until many people are infected by SARS-CoV-2 and recover — achieving the herd immunity threshold.

advertisement

The declaration proposes a vague set of “Focused Protection” measures for the vulnerable older adults, including testing of nursing home staff. The declaration is simplistic and doesn’t acknowledge the scientific uncertainties of immunity to the virus, the long-term consequences of infection, or that young people can — and do — develop severe cases of Covid-19 and sometimes die from it.

This declaration profoundly underestimates the suffering that would result if this strategy were to be enacted.

The declaration glosses over scientific realities. The young are not invulnerable to the effects of SARS-CoV-2 infection. While children tend to have fewer hospitalizations and milder disease than adults, more than 1,000[14] have suffered from multisystem inflammatory syndrome in children (MIS-C) [15]which leads to vascular complications and shock. Risk factors for severe Covid-19 in people of all ages include obesity and diabetes[16] — which encompasses 40%[17] of the U.S. population.

Death is not the only measure of Covid-19’s impact. Many non-elderly adults infected by SARS-CoV-2 have become “long-haulers,”[18] experiencing long-term health effects[19] like cardiovascular and respiratory problems. About 20% to 35%[20] of U.S. patients with Covid-19 have lingering symptoms two to three weeks after recovery. Risk factors may not be obvious, with at least 10 football players[21] developing a heart condition called myocarditis after infection. It is not known what additional long-term consequences may result — we still have a lot to learn about this new disease.

Achieving herd immunity would require recovered people to have lasting immunity, but scientists do not yet know how long immunity lasts. Reinfections are rare, but have occurred[22]. Though much has been learned about the immune response to SARS-CoV-2, and the importance of antibodies[23] and T cells[24], there is no test a person can take to determine if they are immune or to know if their immunity has waned.

Without a vaccine, the human cost to reach herd immunity[25] would be profound. There is a range[26] of models[27] for herd immunity thresholds, depending on how much weight is given to vaccine efficacy, degree of social distancing, and how long immunity lasts. Most models[28], however, indicate it would require 60% to 80% of the population to be infected, which would be a minimum of nearly 200 million cases in the U.S. alone. Approximately 8% of the U.S. population has been infected with SARS-CoV-2, based upon the prevalence of antibodies[29], so significantly more infections would be required, leading to at least 510,000 deaths[30] based on the current fatality rate[31] and equations for herd immunity.

Relying on herd immunity alone would overwhelm hospitals[32]. And infections[33], hospitalizations[34], and deaths[35] would continue to disproportionately impact Black people, Indigenous people, and people of color — something the declaration conveniently omits.

Calls for a herd immunity strategy have been met with strong resistance from experts, including the 12,000 members of the Infectious Diseases Society of America[36], hundreds of signatories to the John Snow Memorandum[37], and 17 public health organizations, led by the Trust for America’s [38]Health[39]. Anthony Fauci of the National Institutes of Health has condemned[40] the idea as “nonsense and very dangerous.”

No country has successfully achieved herd immunity from the coronavirus. The example of Sweden’s approach[41], with minimal social distancing and masking measures coupled with restaurants and schools remaining open, should serve as a deterrent[42] rather than a model, with significant deaths tolls and blows to health care systems.

The U.S.’s goals should echo the science-based, layered approaches of countries such as South Korea[43] and Germany[44]. Leaders in public health note that it is a false choice to either do nothing to prevent infections or shut everything down. The U.S. needs a strategic approach with the commonsense precautions that we’ve heard over and over again. These measures and an eventual vaccine can save lives and livelihoods.

The path ahead cannot rely on magical thinking: herd immunity is not a plan.

Gigi Kwik Gronvall is a senior scholar at the Johns Hopkins Center for Health Security. Rachel West is a postdoctoral scholar with the Center for Health Security and the Department of Molecular Microbiology and Immunology at the Johns Hopkins School of Public Health.

References

  1. ^ remain closed (www.nytimes.com)
  2. ^ to fly (medical.mit.edu)
  3. ^ consequences (www.brookings.edu)
  4. ^ return to normalcy (en.wikipedia.org)
  5. ^ herd immunity (www.jhsph.edu)
  6. ^ through the use of vaccines (www.thelancet.com)
  7. ^ 500,000 or more Americans (www.nature.com)
  8. ^ testified last week (www.forbes.com)
  9. ^ has asserted (www.forbes.com)
  10. ^ espoused such a plan (www.ft.com)
  11. ^ White House “embraces” (www.nytimes.com)
  12. ^ Great Barrington Declaration (gbdeclaration.org)
  13. ^ funded by the American Institute for Economic Research (bylinetimes.com)
  14. ^ more than 1,000 (www.cdc.gov)
  15. ^ multisystem inflammatory syndrome in children (MIS-C) (www.medrxiv.org)
  16. ^ obesity and diabetes (www.cdc.gov)
  17. ^ encompasses 40% (www.cdc.gov)
  18. ^ long-haulers,” (jamanetwork.com)
  19. ^ health effects (www.nature.com)
  20. ^ 20% to 35% (www.cdc.gov)
  21. ^ least 10 football players (apnews.com)
  22. ^ have occurred (www.thelancet.com)
  23. ^ antibodies (www.nature.com)
  24. ^ T cells (immunology.sciencemag.org)
  25. ^ reach herd immunity (www.nature.com)
  26. ^ range (www.medrxiv.org)
  27. ^ models (science.sciencemag.org)
  28. ^ Most models (www.nature.com)
  29. ^ prevalence of antibodies (www.thelancet.com)
  30. ^ at least 510,000 deaths (www.nature.com)
  31. ^ current fatality rate (www.forbes.com)
  32. ^ overwhelm hospitals (www.pnas.org)
  33. ^ infections (www.medrxiv.org)
  34. ^ hospitalizations (www.medrxiv.org)
  35. ^ deaths (www.cdc.gov)
  36. ^ Infectious Diseases Society of America (www.idsociety.org)
  37. ^ John Snow Memorandum (www.johnsnowmemo.com)
  38. ^ Trust for America’s (www.tfah.org)
  39. ^ Health (www.tfah.org)
  40. ^ condemned (www.cnbc.com)
  41. ^ Sweden’s approach (www.thelancet.com)
  42. ^ deterrent (www.usatoday.com)
  43. ^ South Korea (catalyst.nejm.org)
  44. ^ Germany (www.cnbc.com)

Leave A Reply

Your email address will not be published.

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More